ClearMTB Therapeutics is a Danish research-driven biotechnology company building new therapeutic platforms across systems biology, cell engineering, microbiome research and neuromodulation.
We work with a platform-based research model where new biological mechanisms are formalized as therapeutic frameworks. These frameworks can subsequently be translated into concrete treatment programs or partnerships with larger biotech and pharmaceutical companies.
Our research spans multiple disciplines, each representing a unique opportunity to develop the next generation of therapeutics.
Understanding complex biological networks and their interactions to identify novel therapeutic targets and develop more effective intervention strategies.
Advanced design and optimization of cellular therapeutic platforms with a focus on long-term stability, function and clinical translatability.
Developing engineered microbiome-based therapeutics that can coordinately modulate multiple biological pathways in the gastrointestinal system.
Precision neural stimulation frameworks using real-time brain activity monitoring to deliver therapy at optimal moments of plasticity.
Exploring new therapeutic strategies targeting the physical material properties of biomolecular condensates to restore cellular function.
Every platform is designed from the outset with translation in mind — from mechanistic insight to clinically relevant research programs ready for partnership.
Four parallel therapeutic platforms, each based on unique biological insights and designed for translational development.
| Program | Description |
|---|---|
EpiState-Lock Cell Engineering | Computational framework for epigenetic stability in engineered cells. Understanding how trajectory history determines cellular stability and function. |
GutSync Platform Engineered Microbiome | Engineered biotherapeutic consortium. Multiple genetically optimized strains in a single capsule to restore gastrointestinal homeostasis. |
PINNACLE Neuroplasticity Framework | Targeted neural circuit reorganization using EEG-based real-time analysis and closed-loop stimulation during optimal plasticity states. |
Condensate Rheology Modulators Novel Drug Modality | Modulating physical material properties of protein condensates to restore gene regulation and cellular function in disease processes. |
New biological mechanisms, formalized as therapeutic frameworks, ready for translation— ClearMTB Therapeutics research philosophy
A theoretical and computational framework for understanding epigenetic stability in engineered cells. The platform builds on the idea that cellular stability depends not only on the end state, but also on the epigenetic path the cell has taken to reach it.
The framework introduces several key concepts for evaluating and designing stable cellular therapeutics:
A platform based on engineered microbiome therapeutics. The central concept is an Engineered Biotherapeutic Consortium, where multiple genetically optimized bacterial strains are delivered in a single capsule.
Together, these strains produce bioactive molecules that can influence multiple biological signaling pathways in the gastrointestinal system. The goal is to restore gastrointestinal homeostasis through coordinated modulation of the microbiome, immune response and metabolic signaling pathways.
A neuroplasticity framework designed for targeted reorganization of neural circuits. The system uses EEG-based measurement, real-time analysis and closed-loop stimulation.
Stimulation is delivered only in moments when the brain is in optimal learning and plasticity states. The goal is more precise and effective neural modulation — moving beyond broad stimulation toward temporally targeted intervention.
A new therapeutic strategy targeting biomolecular condensates in cells. Instead of blocking receptors or enzymes, this approach changes the physical material properties of protein condensates involved in disease processes.
By modulating viscosity or dynamics in these structures, it may be possible to restore normal gene regulation and cellular function — representing an entirely new modality for therapeutic intervention.
A small, dedicated team driving ClearMTB's therapeutic platforms forward from Fyn, Denmark.
CEO & Founder
VP Communications & Outreach
Research Director
Research Associate
We seek collaboration with organizations that share our ambition to develop the next generation of therapeutic platforms.
Joint research projects and knowledge exchange within our platform domains. We actively seek academic partnerships to strengthen the scientific foundation of our frameworks.
Strategic partnerships for development and validation of new therapeutic frameworks. We are designed to work with partners who can bring these platforms through clinical development.
Translating research findings into clinically relevant programs and treatments. We bridge the gap between biological insight and therapeutic application.